Sentence examples for missing reactions were from inspiring English sources

Based on this information, transport reactions and missing reactions were also appropriately updated to the model.

Other missing reactions were added to the model as non-gene associated reactions to enable the reconstructed network to synthesize metabolites for biomass formation.

Some missing reactions were associated with G. metallireducens genes based on biochemical or genomic evidences and were included in the reconstructed network.

To make the GSMM consistent with experimental data, some missing reactions were added to model There are two pathways that can synthesize DHA, the conventional fatty acid synthesis (FAS) route and the polyketide synthase (PKS) system [ 26].

In the next section, use of the SMILEY algorithm to predict likely missing reactions is presented.

Although very high percentages (66.6%) of the enzymes were associated with the reactions, there were missing reactions that were not represented in these databases.

A protocol encompassing 94 steps details the process including obtaining a draft construction from databases, collecting experimental data, refining the reconstruction by adding details to ensure that the network is mass and charge balanced and that missing reactions steps are properly flagged, to test the ability of the model to grow, and to compare against known properties [ 17].

13, 76, 77 The entire viability of the network is assessed, and structural gaps (created by unconnected metabolites; thus, they are indicative of missing reactions or pathways) are analyzed with the help of literature and with sequence alignments.

Missing essential reactions were identified iteratively; a minimum set of hypothetical reactions was added to the model if an essential metabolite could not be produced otherwise.

Although this oxygen limitation could be exaggerated by the observation that the P. putida model may be missing reactions that enable more oxygen-efficient metabolism [ 36], oxygen is known to be a limiting factor in biodegradation [ 43].

Genome-scale metabolic network models typically contain hundreds of reactions, and are typically missing reactions in their early formulations, since most genome-scale networks are derived from genome annotations that are themselves incomplete.