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The pre-multiplication of the residuals by R i in (2) ensures that those corresponding to missing outcomes do not contribute to Q; the entries of corresponding to missing outcomes are zero.
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For the worst case scenario we assumed that all babies with missing outcomes did not survive to 28 days, yielding an adjusted odds ratio of 1.93 (1.61 to 2.32; P<0.001).
Treating missing outcomes as failures did attenuate the magnitude of the effect, but did not change the overall time trends.
Sensitivity analysis for missing outcome data did not change this effect estimate or substantially reduce the degree of heterogeneity (Additional file 1: Table S6e).
Sensitivity analysis for missing outcome data did not change this effect estimate (Additional file 1: Table S6d), and no evidence of heterogeneity was observed (I 2 = 0%).
Adding values from routine clinic data for missing outcome data did not alter the result (missing data were only evident for three young people in the control group and seven in the intervention group).
Second, for studies with missing outcome data, we did not use imputation methods.
In total, data on 768 burn areas were available, but of these only 310 had mean flux measured, of which 299 were complete, the other 11 having a missing outcome assessment because the patient did not attend one follow-up visit or because of surgery.
All but one trial were assessed as having a low risk of bias because of having no missing outcome data; one study [ 24] did not report the number of participants analyzed in the outcome measure.
Patients excluded due to missing data on long-term outcome did not significantly differ in PaO2 (13.1 kPa, IQR 10.8 to 16.8) (P = 0.394), but they had a slightly lower APACHE II score (22, IQR 19 to 26) than the included patients (P = 0.001).
Because our response matrix had many empty cells – each participant only squatted for four of the eighteen possible recipients – we required a way of ensuring these missing values did not influence the outcome of our analyses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com