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*** In total 101 missing observations due to a missing value for one or more independent variables.
The primary analysis will be intent-to-treat; missing observations due to dropout and other reasons not related to the treatments will be handled with multiple imputation methodology.
Although all patients agreed to wear the actigraphs, twelve actigraphs were worn for less than 48 hours and/or had frequent missing observations due to instrument malfunction.
Missing observations due to incomplete documentation for some laboratory and respiratory parameters reduced the effective sample size in the statistical analyses.
An allowance for loss to follow-up has been included in the sample size calculation; data with missing observations due to loss to follow-up, as opposed to mortality, will be examined to determine both the extent of missing data and whether data are missing at random or are informative.
The dry season data covers 12 days (JD 35 46, February 2005) and the wet season data covers eight days (JD 266 273, September 2005), but with 27 missing observations due to computer failure, probably caused by overheating.
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The observed reduction in risk was not due to missing observations.
It is also shown that these improvements are indeed due to an improved quality of GPS observations around the geomagnetic equator, and not due to missing observations in these regions.
Further, we investigate the application of the proposed methods to unbalanced data from BRSS-structured CRDs due to missing observations and illustrate it with an example using educational data.
The procedure can also be applied to future power evaluations of other cardiovascular parameters, such as the QT interval, and the loss of statistical power due to missing observations.
Furthermore, 1,400 patients were excluded from the analysis due to missing observations in key variables.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com