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Finally, relevant to recent technological advances, supplementing Sanger-derived shotgun reads with sequence data generated with a 'next-generation' DNA sequencing platform (e.g., an Illumina Genome Analyzer) can recover some of the sequence that is otherwise missing in initial assemblies.
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(EdiThat by Edwina Gibbs).
Of course, had the empirical test been negative, this would have meant that at least one item of data (a molecule), or possibly additional EVFs, were missing in the initial aggregate.
False-negative interactions are harder to avoid since if a PPI link is missing in the initial putative network, there is no effective method to recover the link.
For genes that appeared to be missing in the initial PGAAP annotation, the respective genomic regions were examined by additional GLIMMER analysis [ 72] and manual inspection.
Together, while these results argue for ArhGAP44-dependent regulation of Rac1 in actin patches, we agree with the referee that a discussion about the function of Cdc42 has been missing in the initial manuscript.
After already launching in France and the UK, Germany and Spain were the other first tier countries that were missing in Yelp's initial European roll out phase.
We read the abstracts from these articles to identify potential studies for inclusion as well as manuscript citations to identify further manuscripts that may have initially been missed in our initial search.
When a new melanoma is detected in an area where a mole was removed and diagnosed as benign, doctors usually review the microscopic slides to determine if the melanoma was present but missed in the initial testing.
The reference list of the articles that have been retrieved was checked out for additional studies that may have been missed in the initial searches.
The intergenic probe sets that exhibited periodicity may correspond to 5'/3' untranslated regions, genes missed in the initial genome annotation, or short functional RNAs [4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com