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The mutual intersection of all data sets yielded 19,372 diallelic, autosomal SNPs with experimentally determined genotypes (i.e., no imputation of missing genotypes was performed).
The overall rate of missing genotypes was 9%.
Accuracy of filling in missing genotypes was assessed by removing known genotypes at every 50th position for 10% of animals on chromosome 26.
Subjects were excluded if the percentage of missing genotypes was greater than 2% (n = 6).
Imputation of missing genotypes was based on HapMap Phase II genotypes for the European population (CEU).
Haplotype phasing and imputation of missing genotypes was performed with fastPhase [ 40], using default values for each parameter.
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Their missing genotypes were imputed using either Beagle or LDMIP from T densely genotyped candidates chosen from the whole pedigree.
Cost-effective studies using sequence data can be achieved via pedigree-based genotype imputation in which some subjects are sequenced and missing genotypes are inferred on the remaining subjects.
SNPs with ≥2 missing genotypes were excluded.
Based on estimated parameters, missing genotypes are inferred.
For these analyses, missing genotypes were replaced with the mean genotype score for that SNP.
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