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Many are probably redundant and not essential or don't affect health 3% of the missing genes are involved in distinguishing smells, which may have mattered for ancient humans but not for modern ones.
The functions of the missing genes are mostly related to metabolic activity, the production of energy and cell motility, and transcription.
It is clear that the defective tra gene clusters of pO55, pO157 and pSFO157 are not functional for conjugational transfer, as many of the missing genes are required for conjugation [37].
Thus, we cannot exclude that some of the missing genes are actually lost in N. furzeri.
A total of 68 (38%) missing genes are from PE-PGRS gene family.
Many of the missing genes are likely to be closely related so this set may show higher redundancy rate than the background.
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For the reference strain 18323, the missing genes were found in 17 of 20 functional categories.
The three categories without missing genes were replication, recombination and repair, cell cycle control, mitosis and meiosis, and nucleotide transport and metabolism (Figure 3).
Diplotypes were generated based on the 4 studied SNPs, missing genes were imputed.
CGH Result indicated that the missing genes were different in different strains.
For gene prediction software, the percentage of missing genes is strongly correlated with the frequency of gene overlaps.
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