However, it is likely that this number is an underestimate, because expression profiling studies will miss target genes whose expression patterns are altered by Hox regulation, but are still expressed, on average, at similar levels in both tissues.
We also propose extensions to deal with missing values, discover anticorrelated and scaled expression patterns, and different ways to compute the errors allowed in the expression patterns.
We present extensions to handle missing values, discover anticorrelated and scaled expression patterns, and consider alternative ways to compute approximate expression patterns.
Obviously, a missing component in the expression pattern could be because the DNA fragment assayed in the reporter fusion is missing a binding site for a transcriptional activator of relevance to the promoter's activity.
Other informative gene expression patterns may be missed when focusing on gene sets or molecular concepts.
These results support our idea that e-CCC-Biclustering is able to recover genes with relevant expression patterns, that were missed due to small errors, and are in fact, biologically relevant to the problem under study.
In Arabidopsis, several hundred genes predicted exclusively by ab initio prediction programs or through comparative alignment with Brassica have been experimentally validated [ 17- 20], suggesting that many low-expression genes or genes with very circumscribed expression patterns may be missed by the RAP effort.
In this case, and in order to "jump over" the missing value in the time points C3 and C5, we insert in T right two strings corresponding to each of the two contiguous sets of symbols without missing values in the expression pattern of G2: = [D1 U2 $2] and = [U4 $2].
Interestingly, with only one exception, elements of the expression patterns present in the wing were missing in the haltere (e.g. wg, notum, and Distalless (Dll)), suggesting that Ubx is repressing these genes rather than activating them.
However, such relatively low-throughput screenings were biased towards abundantly or ubiquitously expressed miRNAs [ 6] and missed many miRNAs with restricted temporal or tissue-specific expression patterns [ 1].
