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For the external evaluation dataset, missing dosing information on the pharmacokinetic sampling days was imputed from the days prior to pharmacokinetic sampling since dosing was to be stable during this period (309 out of the 311 subjects had imputed dosing at least on one occasion).
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The impact of missing doses of single agents has not been studied extensively.
Almost every elder knows the frustration of missing doses and the concern about potential drug interactions.
ApEn is directly related to the percent of days of missing doses (p < 0.001).
However, even patients with a low percent of days missing doses may have irregular daily dosages.
There can be considerable irregularity in daily dosage despite a low percent of days missing doses.
During the 207 analysis periods, the mean percent of days missing doses of antidepressant was 18.6% ± 22.0%.
Neither the percent of days missing doses nor the drug holidays were associated with any demographic or clinical factors.
Death from status epilepticus is primarily due to an underlying problem rather than missing doses of medications.
For these patients with incomplete adherence, missing doses over a continuous and sustained interval may pose more risk for virologic rebound than interspersed missed doses.
The most common reasons for missing doses were forgetting and side effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com