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The term 'ignorance' refers to the lack of knowledge due to the missing disease status for the not verified patients.
Among autotransplant recipients 54 (39%) were in complete or partial remission where as 78% of the NST/RIC cohort had missing disease status data.
Many papers in the literature discussed missing reference test outcome (missing disease status) and how to correct such bias, so called partial verification bias or work up bias [ 1– 4].
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Participants were eligible for these analyses if they completed the health questionnaire at any two consecutive phases between phase 3 and phase 9 and had no missing data on disease status at the corresponding baseline phases (see Supplement 1 for a detailed description of sample selection).
Even if immunization data for all study subjects is obtained from a registry, however, to the extent that some immunizations are missing from the registry (and that the pattern of missing immunizations is not related to disease status), vaccine effectiveness estimates will be biased toward the null.
Some cases of disease are missed because the ascertainment of disease status is not perfect.
Misclassification of disease status or missed diagnosis may have contributed to the negative findings in this study.
ω imd denotes the missing probability of index test given disease status d in study i.
Let ω imd denote the missing probability of index test given disease status d in study i: ω imd = P r(T= m| D= d).
Thus, some cases of disease are missed because the method used to ascertain disease status for those who test negative on both initial screening tests may not be 100% sensitive.
Potentially missing subjects may have had atypical intermediate trait values or disease status (or other diseases related to the same genotype).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com