Patients with missing diabetes status were assumed to be non-diabetic.
We included only those subjects 20 years and older without self-reported history of diabetes and not missing diabetes status (n = 12,601).
After excluding 16 respondents with gestational diabetes mellitus or missing diabetes status data and 186 respondents with missing physical activity data, we had a study sample of 1,848 adults, 129 of whom reported they had diabetes.
We excluded participants with prevalent (n = 29) or missing diabetes status (n = 81); those with prevalent cardiovascular disease or cancer (n = 162); those without duplicate measurements of δN or δC (n = 7); those with >10 lines missing from the FFQ (n = 13); those missing data on fish, meat, or protein intake (n = 26); or those with missing covariate information (n = 34).
Previous studies registered the diabetes status only once, missing diabetes cases presenting after the sIA diagnosis.
Of the 4,549 participants, 331 with baseline CVD, missing baseline diabetes status (n = 110) or A1C values (n = 334), kidney transplant without self-reported diabetes (n = 1), or dialysis therapy without self-reported diabetes (n = 2) were excluded, leaving 3,850 participants for these analyses.
Of the 10,735 completed interviews, there were 74 missing values for asthma, 310 missing values for limited vigorous activity, 115 missing values for diagnosed diabetes status, 29 missing values for smoking status, 1572 missing values for secondhand smoking exposure, 398 missing BMI values, 33 missing marital status values, and 20 missing educational level values.
Subjects were regarded as censored cases if any of their annual health examination data was missing or their diabetes status was undetermined (missing FPG, HbA1c or questionnaire information) for the first time during the course of the follow-up period.
After excluding 857 (12.5%) participants with diabetes at baseline, 349 (5.1%) without a follow-up visit, 25 (0.4%) missing exam 1 diabetes status, and 12 (0.2%) missing all inflammatory markers at baseline, our final study sample was 5,571 individuals.
We excluded 208 subjects for whom there were missing data on diabetes status, 131 subjects for whom there were missing data on lung function, and 45 subjects for whom there were missing data on other key variables, resulting in 15,408 participants in our analytic cohort.
For the present study, we excluded those individuals who reported that a doctor or health care profession had ever told them they had diabetes (n = 1,900), who were missing information on diabetes status (n = 288), or who were missing A1C data (n = 986).
