It was therefore sensitive to data entry errors and missing data, even though as much effort as possible was made to recover and input missing information and clean the database.
The report, though missing data from some states, paints one of the fullest pictures to date of the actual cost of the 2010 healthcare law's coverage expansion.
Imputation of missing data Repetition of the regression analysis after imputation of missing data confirmed our findings, though with lower values for odds ratios but narrower confidence intervals.
There was a good response rate for the second stage of data collection (80% of families), though missing data on BAS-NV or key confounders led to the exclusion of 3793/14 376 singletons (26%).
Limitations include the exclusion of 362 patients with missing data on SEP variables (though these did not differ statistically from the study population with regard to age, sex, or survival (data not shown)), a potential risk that the ECOG performance status was scored in retrospect in a few number of patients, and a high number of missing data on treatment variables.
They should also check whether important predictors are recorded in each study, and evaluate the amount of missing data for available predictors; though multiple imputation can limit these issues, studies with multiple missing predictors or large proportions of missing values might be best excluded for robustness (unless imputation assumptions can be justified).
The severity of the events, and the fact that women experiencing them would subsequently be monitored by their GP, however, means that missing data should be minimal, though this is still a limitation of general practice electronic medical records data in general.
At the trial level, nine were at high risk of bias for missing data and 12 were unclear, though missing data for the primary outcome was not a concern.
In the first instance, missing data will not be imputed, though the sensitivity of the main findings will be assessed under alternative assumptions regarding missing values (such as last observation carried forward).
Performance status was not significant though there were missing data from 40% of patients.
