Exact(3)
Briefly, all analytes that passed QC checks based on the following four criteria (standard curve linearity, intra-assay coefficient of variation [CV], interassay coefficient of variation for reference sample, and percentage of missing data; Supplementary Material S4) were taken forward for further analysis.
The final matrix is composed of 682 orthologous groups (192,464 characters) containing only one gene per genome and no missing data (supplementary data S1, Supplementary Material online).
FACT-P scores at baseline were similar between the two treatment groups (Table 1) and consistent with the mean reference values for patients with advanced prostate cancer [ 6].> -wrap-foot> Overall, 67.2% and 31.8% of patients in the enzalutamide and placebo groups, respectively, had no missing data (supplementary Table S2, available at Annals of Oncology online).
Similar(57)
Few variables had lots of missing data (see supplementary appendix 4).
A conservative 'no vitamin C effect' estimate was imputed for all the nine participants with missing data (see online supplementary file 2).
Similar results were found in the second reading and a range of sensitivity analyses to assess the impact of missing data (see online supplementary table S1).
Overall, these findings were largely replicated in a complete case analysis with no imputation of missing data (see online supplementary table S5).
The main effectiveness analysis was completed on an intention to treat (ITT) basis with imputation of missing data (see online supplementary text S2 and S3 for full details of analysis methods).
29 Unless where noted, after exclusion of patients whose diagnosis did not involve a prereferral consultation and missing data (see online supplementary appendix 2), complete case analysis was restricted to 740 patients with bladder cancer and 287 patients with renal cancer with at least one known prereferral consultation.
Partial sequences, positions ambiguously aligned or containing more than 70% of gaps and/or missing data were deleted (see supplementary table S2, Supplementary Material online for details about sequences).
Due to the large amount of missing data on certainty classifications (Supplementary Note 2), trends arising from data on the certainty classifications are likely to be misleading.
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