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Two studies were missing data required to calculate effect sizes.
An additional three respondents were excluded due to missing data required for weighting purposes.
Participants (n=36) with protocol violations or missing data required for the primary model were excluded (n=1543 analysed vs n=1579).
The fully sampled volume required 1.6s for acquisition, and the CS volumes at 36, 48 and 65percentt missing data required 1.02s, 0.83s and 0.56s, respectively, for acquisition.
Although these studies were excluded from the meta-analysis due to missing data required for calculating effect size, they did adhere to the fidelity of the strengths model.
After excluding 250 patients with international normalized ratio < 1.3 and/or missing data required for analysis, we compared all-cause 30-day case fatality using Cox regression.
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Most statistical methods for missing data require some assumptions on missingness mechanisms.
Many existing statistical methods for missing data require observations at individual levels.
Careful consideration of the missing-data mechanism is important because different types of missing data require different treatments (Allison, 2000; Schafer, 2003).
Since DIVAS variants are derived from a variety of sequencing and genotyping platforms, some variants are not profiled and missing data require imputation.
However, the implementation of mixture models quickly becomes more complex at higher numbers of covariates with missing data, requiring x n subpopulations in the mixture model for n covariates with missing data and x categories per covariate as well as a multitude of additional lines of code to cope with the estimation of the covariate effects.
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