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Large volumes of data were entered remotely at each study site using a standard web-browser, and the system allowed both the study site staff and the Coordinating Center to monitor progress and produce missing data reports in real time.
Although there is an abundance of statistical literature about missing data, reports of epidemiologic studies dealing with missing data in the context of self-rated psychopathological symptoms are rare [ 7].
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27 (35%) trials with missing data reported a sensitivity analysis.
Furthermore, as recommended, the statistical methods, missing data reporting, and use of sensitivity analyses were judged.
with missing data and their handling of missing data; reporting sensitivity analyses regarding missing data; and reporting an intention to treat analysis.
For each review we reported, if possible, the number of trials: included in the review, with missing data, reporting sensitivity analysis, reporting ITT, and missing data approaches.
In 52 articles the amounts of missingness, if any, were specified for all the reported variables; 15 with no missing data reported and 37 with some missingness.
The aims of this study, therefore, were to identify, in RCTs published in the top medical journals, the proportion of trials: with missing data and their handling of missing data; reporting sensitivity analyses regarding missing data; and reporting an intention to treat analysis.
Missing data patterns were analysed by preparing a missing data report (% missing) for first-order questions (no skip patterns or secondary data) to identify data elements that required further work and cases to be excluded if more than 50% of data was not retrieved across all settings.
For example, the evidence of skew reported here may be accentuated by non-response (if patients with poor experiences are less likely to respond), and the levels of missing data reported may be low because respondents are more likely to be literate and used to completing forms.
Data extraction was undertaken by one member of the research team and summarized using items presented in Table 1.> The quality of a study was assessed by examining the risk of bias from the methods of patient recruitment, and noting any missing data reported either study drop-outs or incomplete questionnaires.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com