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To prevent missing data, patients will receive reminders for the questionnaires if they do not return the questionnaire within three weeks.
Unit-level missing data (patients not providing data for a whole measurement point due to dropping out of the study, for example) will be imputed via the EM algorithm using existing information from the baseline assessments.
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At inclusion 36 patients (41.4%) started treatment with cannabinoid oromucosal spray.> -wrap-foot> *1 patient with missing data; **5 patients with missing data; ***2 patients with missing data; ****38 patients with missing data.
After excluding the 105 patients who had in-hospital stroke and the 92 patients with missing data, 3054 patients were used in the analysis.
Among patients without missing data, responder patients were 79.1% in the mesalazine group versus 78.3% in the placebo group (p=0.904; difference=0.8%; 95% CI −12.9% to 14.6%).
We excluded patients with partially missing data, and patients emigrating were censored at the time of emigration.
A total of 317 patients were excluded due to missing data: 298 patients were missing data on one or more cognitive tests; 12 were missing data on self-care, and seven were missing both cognition and self-care data.
There was no systematic reason for missing data and patients with missing data were similar to other patients.
Results: After accounting for missing data, 15 patients out of 330 (4.5 %) died or were escalated to the critical care unit.
Additional file 1: Overview of missing data in patients and control subjects.
There was no missing data; all patients were successfully located at 36 month follow-up.
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