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A complete deletion of the gap and missing data information was applied.
In order to model missing data, information about three of the variables listed is needed.
In the case of missing data: information about growth, DKA admissions and severe hypoglycaemia is sought from clinical records.
After excluding patients with missing data, information was available for 2396 patient visits resulting in 2458 diagnoses.
In case of missing data, information was completed from surveys subsequent to baseline but prior to the 2002 2004 follow-up, requiring that the participant was still employed; the follow-up and length of follow-up was calculated accordingly.
In this mode, when the choice among multiple sequences for an OTU is ambiguous, the software guides the user by providing the average evolutionary distances (to reduce LBA) as well as missing data information.
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A small percentage (2.92%) of patient data contained missing or erroneous information and could not be transferred to the clinical codes due to ambiguity.
Where we have missing or unclear data or information, we will contact the investigators of the primary research.
Additionally, for exome and genome sequencing data, we included flanking intronic regions and developed a method to impute missing sequence data based on phylogenetic information.
Such work however would require comprehensive experimental effort to provide the missing kinetic data and other quantitative information to calibrate and validate the model.
Finally, after excluding 145 of those followed-up (3.4%) because of missing frailty index data, we analyzed information on 4082 participants (92.2% of those directly interviewed).
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