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When patients with missing data differ from the other patients on prognosis, this causes a bias in the regression coefficients and the estimated 5-year survival rates (Little, 1992; van Buuren et al, 1999; Clark and Altman, 2003).
On the other hand, MI may produce biased estimates if the data are 'Missing Not At Random' (MNAR), which occurs when the study participants with missing data differ from the study participants with complete data in a manner that cannot be explained by the observed data in the study [ 13].
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The amount of missing data differed by variable as different sets of variables were collected at different times.
Second, we did not have race/ethnicity data for 19% of the case-patients in our study; if the rate of missing data differs across race/ethnicity groups, the estimates of incidence by race/ethnicity may be biased and could underestimate the true incidence of disease in at least some groups.
Misclassification or reasons for missing data could differ by gender, potentially distorting the observed pattern of effect modification.
The patterns of missing data may differ between case and control patients and thus may have influenced the calculated scores.
While children with missing data did differ on some variables for some models there was no clear pattern for these children in terms of advantage or disadvantage in relation to the primary or secondary explanatory variables.
A further limitation of the current analysis was the missing data, which differed by treatment group, suggesting that the scale may be more acceptable or relevant to participants with T2DM using insulin than non-insulin using participants.
If participants with missing data and complete data differ with respect to exposure and outcome, estimates of association based on fully observed cases (known as a complete-case analysis) might be biased.
Patients with missing data did not differ from the included patients on nonadherence measures.
Misclassification or reasons for missing data could also differ by gender, potentially distorting the observed pattern of effect modification.
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