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Four of the 60 patients that had reported PFS time had more than 10 missing values, and they were excluded before imputing missing data according to the following protocols: http://www-stat.stanford.edu/hastie/Papers/missing.pdf [29].
Otherwise there was little pattern in missing data according to specific items.
The number and percentages of missing data according to the items of the questionnaire are summarised in Table 1.
We estimated missing data according to each of the four imputation algorithms, and then filtered data to exclude markers with minor allele frequency < 2.5%%.
Thus, data on TNM stage should be used with caution in epidemiological and other research, with consideration of missing data according to age and level of comorbidity.
Among the 82 papers meeting the inclusion criteria, only 35 (43%) reported the amount of missing data according to the suggested guidelines.
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Three types of missing data exist according to Little and Rubin's classification [ 5].
Although this criterion is best to minimize the quantity of missing data, selection according to evolutionary distances allows a more judicious choice of sequences (see below).
The statistics files produced by SCaFoS allow an easy monitoring of the missing data level according to these criteria (Fig. 4).
We will describe the sample by calculating the proportions of responses and non-responses for each variable and for the questionnaire overall and then we will investigate whether patterns of missing data vary according to key sociodemographic characteristics.
We compared children with and without missing anthropometry data according to baseline characteristics (birth weight, birth length, maternal U-As in early and late pregnancy, child U-As, and SES) and found no significant differences between groups (data not shown).
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