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The missing control group remains an important limitation of the study.
Risk of bias within studies was high for all included studies mainly due to flaws of study design, assignment of patients to treatment groups, and missing control for confounding (Table 4).
Risk of bias within studies was high for 21 of 26 included studies mainly due to flaws of study design, assignment of patients to treatment groups, and missing control for confounding (Table 6).
One essential missing control in this data figure is the IPA-alone control lanes.
The shortcomings of the study are the missing control group and the small sample size.
Of the five patients with missing control status, three were male and two were female.
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Some of the missing controls are spin control, combo-box, tree control, and tabs.
Through an empirical study, we demonstrate how the OPL method allows for a quantitative estimation of the importance of in-place security controls as well as the CDR of missing controls.
If the authors can address the concerns of the missing controls, I would support its publication.
Many of them deal with seemingly missing controls and/or simple experiments to more rigorously challenge the in vitro model.
However, there are some important, missing controls, and the efficiency of co-transduction of linked genes needs to be discussed in greater detail.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com