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Fourteen patients were excluded due to missing clinical data.
Additionally, among the original 260 T2DM participants recruited for the study, 19 were excluded, mainly because of missing clinical data.
There are also inherent limitations of a retrospective chart review, such as the lack of clinical homogeneity among the different sites, missing clinical data, and variability in data abstraction.
One article had to be excluded or pooled with another because of possible double publication of the same cohort (Grecchi (b) [15]), one article because of missing follow-up times (Hvaring [16]), one because of missing clinical data (Kjaer [17]), and two articles because of missing numerical data (Dellavia [18, 19]).
Of these 247, patients were excluded from the study due to: missing clinical data (n = 86) or inadequate paraffin-embedded fixed tissue blocks (n = 161).
Of these, 247 patients were excluded due to missing clinical data (n = 86) or inadequate material for histological examination (n = 161).
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With the substantial cost associated with producing clinical registries such as APPROACH, and the commonly associated challenge of missing clinical registry data, our data merging method and translation to ICD-10 can be of value to other researchers.
Missing clinical outcome data and resource use (due to non-consent for the release of Medicare and PBS data or failure to complete the health utilization questionnaire at 6 or 12 months) were managed using a multiple imputation method via chained equations imputation generating 5 imputed datasets [ 4, 24].
Patients with missing clinical outcome data or indeterminate responses were considered to have failed treatment in the intent-to-treat (ITT) and microbiological ITT (MITT) analyses, but were excluded from the per-protocol (clinically evaluable [CE] and microbiologically evaluable [ME]) analyses.
Physicians regularly receive enquiry forms to complete missing clinical and therapeutic data.
Non-responder imputation was used to handle missing clinical and radiographic data.
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