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Of 1,791 patients in the study, 141 were missing baseline measures of eGFR, leaving 1,650 subjects eligible for analysis.
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Participants missing baseline glucose measures, family information, physical activity data, smoking information, or BMI measures or who were <18 or ≥75 years old were also excluded (n = 472).
Participants missing baseline glucose measures, family information, <18 or ≥75 years of age, or who had less than 3 days of pedometer data were also excluded.
*Analyses with multiple imputation for missing baseline and follow-up data points adjusted for baseline measures of outcome and minimisation variables (practice deprivation and practice size).
Although protein C activity levels were measured in the PROWESS trial, patients with missing baseline protein C activity values were excluded from these analyses.
For continuous outcomes, analyses will adjust for the minimisation factors and the outcome measured at baseline (provided there is no substantial missing baseline data).
Patients who had missing baseline protein C values did not significantly differ from the overall population in baseline characteristics, disease severity measures, or outcomes (data not shown).
We excluded the participants with missing baseline FFQ data or with ten missing FFQ lines as well as those with unavailable information on lipid measures.
In order to increase the precision of estimated intervention effects continuous measures will be analysed with adjustment for the baseline covariate prior to the first randomisation, if available, with missing baseline data included by the missing indicator method [ 27].
We excluded re-admissions and cases with missing baseline data.
Firstly, overall mean scores at baseline substituted missing baseline scores.
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