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Missing baseline Disease Activity Score in 28 joints (DAS28) values did not preclude enrolment.
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Subjects with missing baseline data (n = 6) and subjects with heart disease, stroke, chronic liver disease, kidney disease or any type of cancer at baseline (n = 3413) were excluded from the analysis.
One patient lacked information about extent of disease, two patients had missing baseline PSA information, and a further 173 were missing clinical stage, leaving 585 with a CCP score and all clinical variables for analysis in the primary analysis cohort (Supplementary Figure S1).
Patients who had missing baseline protein C values did not significantly differ from the overall population in baseline characteristics, disease severity measures, or outcomes (data not shown).
The handling of missing baseline values varied: some used admission creatinine, some used back calculating with the Modification of Diet in Renal Disease (MDRD) formula, and one study used multiple imputation.
We excluded re-admissions and cases with missing baseline data.
Three of these women were missing baseline data and thus were excluded from the baseline and multivariate analyses.
Firstly, overall mean scores at baseline substituted missing baseline scores.
There were 258 missing baseline viral loads and 25 missing baseline CD4 counts.
Patients with missing baseline values were excluded from these analyses.
Patients missing baseline clinical data were imputed using median values.
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