However, like a number of other approaches on metabolite set enrichment analysis, the projection of enriched metabolites is done on pathways instead of the whole network, thereby missing (alternative) pathways not annotated in current databases, or more generally paths traversing several pathways.
Barplots of differentially enriched GO terms (from one genotype/organ/treatment missing in the alternative genotype in the same organ/treatment) in the roots, as estimated by goseq at an FDR cut-off of 0.05.
Barplots of differentially enriched GO terms (from one genotype/organ/treatment missing in the alternative genotype in the same organ/treatment) in the leaves, as estimated by goseq at an FDR cut-off of 0.05.
If any criteria are missing in an alternative, this alternative should be withdrawn from the decision process or given an extremely low symbolic value to the missing criterion.
Several GO terms were genotype-specific (i.e., enriched GO terms from one genotype/organ/treatment missing in the alternative genotype in the same organ/treatment).
Figure 2 shows the interaction between CUL4A and DDB1 and highlights the region of CUL4A that is missing in the alternative isoforms.
The MES performs this task in an autonomic manner, filling in missing details, providing alternatives for unfeasible assignments, handling auxiliary tasks, and so on.
The discovery of the missing enzyme in the alternative pathway opens the door to the re-examination of many other living things, to find which have the new pathway and to work out why.
In the past, when a photographer picked up prints from the shop and found images conspicuously missing, her alternative was to learn to develop her own photographs.
These data are missing for alternative formalin-free fixatives.
