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Limitations of our study include some missing address information, which was corrected in part through multiple imputation.
This left a further 956 scan records (2% of all recorded scans) excluded due to missing address information.
This was either due to missing address information, incompatible street number suffices, or to addresses situated outside of the study area of the Generation R Study [ 16].
Reasons for nonparticipation for the eligible controls included refusal (22percentt); could not be contacted (14percentt); missing address information (6percentt); and parents were divorced or widowed (2percentt).
The proportion of case and control mothers missing address information was similar (11.4% and 10.5%, respectively), and there were no significant differences on demographic factors between those with and without a maternal address at delivery.
The reasons for nonparticipation for the eligible cases included refusal (2percentt); could not be contacted (1 percent); missing address information (2percentt); and parents were divorced or widowed (1percentt).
Similar(51)
To confirm whether there may have been residual confounding due to missing address level data, ancillary analyses were conducted to determine whether differences existed in median county level pre-1950's homes, household income and poverty levels among addresses with complete address level information compared to those with missing information.
Multiple gestations were excluded (5%) as well as subjects with unsuccessfully geocoded addresses, missing addresses or missing important covariate information used in previous studies (12%) [ 13, 16].
In this analysis, participants were excluded due to residence outside of the continental United States (2% of participants), invalid address information (6%), missing BP measurement (0.3%), missing modeled NO2 estimates (0.06%), or other missing key covariate data (6%).
Of note, among the 38 blood donors that were seropositive for Leishmania, 26/38 (68%) currently live in Salvador whereas 8/38 (21%) live in adjacent municipalities (address information was missing from four samples).
Follow-up analyses, however, indicated that address information may be differentially missing for the highest ED-utilizing enrollees.
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CEO of Professional Science Editing for Scientists @ prosciediting.com