The real Richard's skeleton shows he suffered from scoliosis – which made him short, but not especially misshapen.
Unlike a rustic bloomer, slumped languorously across its baking tray, or a batch of misshapen floury baps, or even a proud sandwich loaf in its tin, bagels don't seem like the kind of bread that could be made at home.
I confess, I fell into a similar trap when it came to George W Bush's burgeoning painting career, particularly when he left his Putin's misshapen face period and entered his kitty cat with an attitude problem phase.
Dr Prusiner, who works at the University of California, San Francisco, has championed the idea that a range of brain disorders including Creutzfeldt-Jakob disease (CJD) in man, bovine spongiform encephalopathy (BSE, or "mad-cow disease") in cattle, and scrapie in sheep are caused by misshapen proteins called prions.
Eventually, the misshapen forms predominate, and the animal dies with its brain full of holes.
A bearded young man gestures urgently at his misshapen right ear.
Part of the reason that breathing becomes hard for emphysemics is that their rib cages and diaphragms become enlarged and misshapen as their lungs expand.
Instead, they are caused by misshapen brain proteins (prions) which have the strange characteristic of acting as catalysts that cause normal versions of the protein to reconfigure themselves as prions.
What makes prion protein unique, according to the Prusiner model, is that misshapen molecules of it somehow cause well-formed ones to become misshapen too.
ABOUT to turn 40 and bruised by the end of his marriage, Jasper Rees, a British journalist, climbed up to his attic and found a misshapen case containing his childhood nemesis: a French horn.
The current immigration laws are like an old, misshapen quilt with ripped seams and the stuffing falling out in places.
