Sentence examples for missense mutant from inspiring English sources

However, the missense mutant, A239V, had 90% of the wild type activity.

We further showed that Tob, but not the Tob D95A missense mutant, suppresses the deadenylase activity of CNOT7 in vitro.

CDH1 missense mutant cell lines derived from families with missense mutations in the extracellular domains of E-cadherin were correspondingly less able to suppress EGFR signaling than cell lines with wild type E-cadherin [27 29].

This work describes the achievement of a knock-in model, which reproduces a mutation of the UROS gene responsible for a severe UROS deficiency in humans (P248Q missense mutant).

Here we present the haploinsufficient phenotype of Dll1 and a missense mutant Dll1 allele (Dll1C413Y).

The missense mutant allele icoII032 was created by EMS mutagenesis [11].

To further investigate the deleterious effects of EF-G1 missense mutant proteins, we expressed the II032 mutant form CG4567-G538E in various tissues.

The MEN1-associated missense mutant A309P maintained the interaction with HMT activity while the A242V mutant did not, consistent with previous reports [12].

Taken together, these results indicate that the unique C-terminal tail of EF-G1 contributes to the growth and pattern defects caused by EF-G1 missense mutant proteins.

The proteins expressed by the missense mutant transgenes used in this study are not degraded and similarly stable as the wild type forms.

Expression of missense mutant forms of EF-G1 can accumulate in the nucleus and cause growth and patterning defects and animal lethality.