Sentence examples for missense modifications from inspiring English sources

Regarding the proportion of silent changes (approximately 48%) and missense modifications (approximately 51%) in the two genotypes, 'Indo' exhibited a value of 1.0917 for missense/silent, which was similar to the value of 1.0449 observed in 'Su Shuai'.

The proportion of silent changes (around 39%) and missense modifications (around 58%) among the three genotypes is relevant since the former are considered as evolutionarily neutral (however, these silent changes can affect the structure and function of the resultant protein, see [ 56]) and the latter are not.

This predicts the missense change p.Met810Arg.

Our results support that, from an evolutionary perspective, the proportion of missense and silent modifications, as well as the ratio between these modifications, indicate a strong effect of artificial selection on the peach genome over the last 100 years of cultivar breeding.

Silent mutations do not modify amino acids, missense mutations induce amino-acid modifications, truncation mutations induce a premature STOP codon in the reading frame.

An intact N-terminus is needed for the nuclear FBXO7 localization, as N-terminal modification by PARK15-linked missense mutation, or N-terminus tag leads to cytoplasmic mislocalization.

Missense substitutions in the BTB/POZ domain cause protein modifications.

For example, Hudson et al.[ 2] stated that transcription factor (TF) modifications such as reversible phosphorylation and missense mutations can act independently of TF expression levels and that such a process can be overlooked by standard differential gene expression analysis.

Thus, missense mutations in this region can cause a modification that may alter DNA binding.

The amino acid position of missense variants in functional domains, disulfide bonds, or posttranslational modifications was verified, as well as their effect on protein tridimensional structure, when available, using NCBI Protein (http://www.ncbi.nlm.nih.gov/protein) and UniProtKB (http://www.uniprot.org/).org/

We also show that an intact N-terminus is essential for proper nuclear localization of FBXO7 isoform 1. Modifications in this region of FBXO7, including the missense T22M mutation or N-terminal tagging by eGFP, lead to mislocalization to the cytoplasm.