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If patients with headache were not clearly excluded by the eligibility criteria, they were deemed to be a missed eligible patient.
Patients were selected without bias and did not differ significantly from missed eligible patients.
Study nurses also reviewed all records of emergency department visits to identify any missed eligible patients.
First, like any other systematic review, the possibility that we missed eligible studies could exist.
These missed eligible patients had similar demographics and EDLOS as the patients that were included, making selection bias unlikely.
If we could not conclusively determine that they did not meet our eligibility criteria on review of the emergency department visit we deemed them as "missed eligible".
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Evaluating patient eligibility based on partly missing data risks missing eligible patients and the introduction of selection errors if the distribution of missing data is not completely random.
We will manually investigate ambiguous literature to avoid missing eligible trials.
The dialysis centre for various reasons might inadvertently miss eligible cases or report cases that are not eligible.
However it has the limitation of having to rely on key informants of varying ability to find the women and the possibility of missing eligible cases.
The detailed search strategies for MEDLINE are presented in online supplementary appendix 1. Bibliographic references in relevant publications (eg, anaesthesiology and pain medicine textbooks, other review articles and included clinical trials) will be manually searched to avoid missing eligible trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com