My favorite Jan Hooks Southern-accent bit is her portrayal of Miss Georgia, Blair Dixon, a contestant in the 1988 "SNL" sketch "Miss Self-Esteem U.S.A. Pageant".
Martelli, A. Velardi, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, in press].
However, NK cell-mediated cytotoxicity is "MHC unrestricted", which means that NK cells kill target cells that don't express MHC class I molecules, a guiding principle in the NK field, also known as the "missing self" hypothesis (Karre et al., 1986; Ljunggren and Karre, 1990).
It is now known that the MHC makeup on the surface of those cells is altered and the NK cells become activated through recognition of "missing self".
Murine natural killer (NK) cells express inhibitory Ly49 receptors for MHC class I molecules, which allows for "missing self" recognition of cells that downregulate MHC class I expression.
In this manner, loss of class I MHC protein from the surface, i.e. "missing self", can render cells susceptible to NK lysis [9], [10], [11], [12].
Mean proportions of Hits (self hand correctly attributed to self), Misses (self hand incorrectly attributed to other), Correct Rejections (other's hand correctly attributed to other) and False alarms (other's hand incorrectly attributed to self) are presented separately for the "Active" and "Passive" conditions in Figure 3.
A presumed reason for this under-representation would be that NK cells with too high affinity for self MHC class I are excluded from the repertoire, as they would be less sensitive to normal cells with downregulated MHC class I expression (missing self recognition).
NK lymphocytes are capable of killing cells with missing self (that is, HLA class I expression).
Thus, the impact of disease heterogeneity on the conflicting effects of a missing self model was excluded.
Missing self reported data could occur at the questionnaire level or at the item or scale level.
