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To investigate this phenomenon further, misreading in the absence of eEF1Bγ (tef3Δtef4Δ) was assayed at the remaining 5 missense codons.
The response to this therapy in all 10 patients with improvement of both symptoms and barium oesophagram supported the diagnosis of achalasia and suggest that the low LOS pressures were due to misreading in the manometry.
The first Monte Carlo simulation to compare the standard code with random, alternative codes has been described by Alff-Steinberger [ 11] and indicated that the standard code outperforms most of the random codes if the differential effects of misreading in the first or third base position are taken into account (two sets of 200 codes each were produced).
In contrast, the data reviewed by Woese (1965) for poly-U show no sign of transition biased misreading in the first codon position at all, but a sign of it in the second codon position.
Similar(56)
Because the same substitution is also seen in the variant P. ovale, P. falciparum, P. vivax, P. malariae, P. reichenowi, and P. cynomolgi (data not shown), this nucleotide may have been misread in the sequence of the Nigerian I/CDC strain; if so, sequences of classic-type isolates are identical to those of the Nigerian I/CDC strain.
In order to shed new light on the biological relevance of mistranslation we have generated codon misreading in Saccharomyces cerevisiae using drugs and tRNA engineering methodologies.
In order to overcome these limitations, we have engineered regulated codon misreading in yeast using a tRNACAGSer that misreads leucine CUG codons as Ser (tRNACAGSer).
About a particularly poorly informed dispatch Yale sent to the State Department, Anderson says: "He was establishing a tradition of fundamentally misreading the situation in the Middle East that his successors in the American intelligence community would rigorously maintain for the next 95 years".
In short, the west misreads "secularism" in the Muslim world as synonymous with hostility to religiously-inspired movements.
Conventional instruments can be misread in a crisis - or so says the inventor of what he claims is a more intuitive design.
Dayan has been critical of both Barack Obama for "misreading" the Middle East — the right, in general, is convinced that Obama "lost" Egypt — and Netanyahu for delivering the Bar-Ilan speech, three years ago.
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