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Summed mismatch score.
Apical mismatch score.
Non-apical mismatch score.
The apical mismatch score (A-MS) and non-apical mismatch score (NA-MS) were also calculated using the same procedure as with SMS.
The summed mismatch score (SMS) was then calculated by deducting SMDS from SBDS.
On the SPECT images, MIBI and BMIPP defects were quantified using a 17-segment model with a 5-point grading system and a summed MIBI defect score (SMDS), summed BMIPP defect score (SBDS), and summed mismatch score (SMS) were calculated.
Similar(22)
Furthermore, apical and non-apical MDS, BDS, and mismatch scores (A- and NA-MDS, A- and NA-BDS, and A- and NA-MS) were calculated.
Without such a consideration, the alignment is more sensitive to user-supplied parameters such as match and mismatch scores, and gap opening and extension penalties.
While my implementation of the aligner permits changing the match and mismatch scores, I chose to use +1 and -1 in all simulations.
The reason is, Maximum parsimony is based on the mismatch scores of reconstructed ancestral sequences, which are similar in case of closely related sequences for example different strains of a species.
For each strain, a match in the marker genotypes was scored 1, and a mismatch scored 0. Strains with missing genotype data at the marker locus were not used in the calculation of the matching coefficient, which was assessed by dividing the total number of matches by the total number of strains with no missing genotypes.
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