In replication replicators do not blend.
Exo1 is a 5'-to'3' exonuclease active in resection of DSB ends in the homologous recombination pathway and it has other roles in replication and mismatch repair [ 17, 39].
In the replication-based mechanisms (FoSTeS, RS, and MMBIR), microhomologous sites are used for priming in replication, and mismatches in these sites are rare.
These mutator effects suggested a defect in replication fidelity at a step preceding mismatch repair (for example, reduced polymerase base selectivity and/or proofreading) [ 7].
We have demonstrated that siRNA targeting either wild-type HIV-1 or M184V variants inhibits replication of the corresponding virus, but does not influence replication of virus with a mismatch in the targeted region.
MSI is frequently indicative of a defect in DNA mismatch repair during replication, either through inheritance of nonfunctional DNA repair genes or through somatic inactivation of repair genes within the cancer cell progenitor [ 36].
However, there are methyltransferases (MTases), such as dam, that do not fall in restriction-modification systems and are important in chromosome stability, mismatch repair and replication [ 11].
The O-methylguanine (O-meG /cytosine (O-meG /cytosinean result intO-meG C-meG:T mismatch in the prO-meG CNA after a first round of repairation.
MutS and DinB are proposed to play opposing roles in P. aeruginosa pathoadaptation: MutS acts in replication-coupled mismatch repair, which acts to limit spontaneous mutations; in contrast, DinB (DNA polymerase IV) catalyzes error-prone bypass of DNA lesions, contributing to mutations.
Effect of S-ODN1 sequence conservation on its inhibitory effect of HCV replication results is shown in Figure 4; one nucleotide mismatch in S-ODN 1 did not show effect on inhibition efficiency of the antisense oligonucleotide; furthermore, both S-ODN1 and its one nucleotide mismatched derivative were able to inhibit replication in HepG2 cells while both failed to inhibit replication in PBMC.
