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Constraint can then be inferred directly by estimating the parameters of the mutation-selection model without the potentially misleading estimation of conservation with respect to a reference sequence.
as missing data to avoid potentially misleading estimation results.
Too many simple models may be useless or even counterproductive, giving a misleading estimation of a patient's clinical risk.
An important issue with such methods is that they will often lead to a misleading estimation of precision, which is often overestimated.
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Recombination can mislead phylogenetic estimation and positive selection analysis.
We limited our model to two populations, since we had sequence data from only 12 or 17 loci, and an insufficient amount of data can mislead the estimation of posterior probability density when more populations are considered [ 59].
However, using the GFs calculated under such rather simplified elastic conditions seems to be misleading in the estimation of afterslip distribution, since the subsurface structure of any region, especially that in and around Japan, is more or less inhomogeneous, and such inhomogeneity should affect, to a certain extent, the surface displacements.
However, if effective actions are taken based on BCS and revealed as a comparison effect, the data will be useless or even misleading for the estimation of relations between the ratings and a given outcome, or between the rating as outcome and some explanatory variable.
Furthermore, the shared content of the array is also misleading for the estimation of cassette gain/loss events, as shared cassettes do not necessarily represent an evolutionarily conserved trait, but can have different histories, as is suggested by the lack of conservation in gene order between the arrays as opposed to the relatively conserved organization of the surrounding genomic genes [ 19].
In terms of variation, the individual breath concentrations show very large fluctuations that often mislead CH4 estimations.
On the other hand, it is likely that the fossil record does not accurately represent actual ancestral distributions, and thus, may be misleading for ancestral area estimations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com