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It was likely that any bias introduced by this exposure misclassification was nondifferential.
Because we based LUR estimates on the women's residential addresses, we assumed that these two subsets suffered less from exposure misclassification and that misclassification was nondifferential.
We assumed that exposure misclassification was nondifferential and independent for cases and noncases, as the data in our study were prospectively collected.
Exposure misclassification due to inaccuracy in individual exposure estimates might have occurred; if exposure misclassification was nondifferential, it most likely would have resulted in attenuation of risk estimates.
15 We calculated the corrected estimates using a sensitivity of 50%, 70%, and 90% and assumed that misclassification was nondifferential and independent for cases and controls because the data were recorded prospectively.
It is therefore possible that findings from previous studies evaluating the interaction of acetylation status and exposure to tobacco smoke in relation to breast cancer risk may have generated spurious estimates of interaction, even if the misclassification was nondifferential.
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However, these sources of exposure misclassification are nondifferential and would bias results toward the null.
Nevertheless, if the misclassification is nondifferential, any potential bias will tend toward the null.
Although the misclassification is believed to be stronger in Greenland, we believe that any misclassification is nondifferential.
However, if this exposure misclassification is nondifferential, it would bias our estimates of effect toward the null.
These sources for exposure misclassification are nondifferential, and we assume that exposure misclassification resulting in bias toward the null may have potentially occurred in this study.
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