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This, plus imprecision of the personal monitor for OC, may have increased misclassification of personal OC exposure and weakened associations.
Furthermore, the present significant associations of F eNO with both personal and ambient EC and NO2 suggest that despite potential misclassification of personal exposure, ambient data linked to combustion sources represents casual pollutant components.
However, it is likely that most misclassification of personal exposure introduced by relying on traffic indicators is nondifferential with respect to AMI and will lead to an underestimate of the association.
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To further quantify dose and reduce exposure misclassification, a number of personal factors (e.g., bottled water consumption, duration and frequency of showers and baths) were considered.
Consequently, residence-based non-ambient generated sources of PM (such as environmental tobacco smoke and cooking) and occupational sources (such as diesel exhaust) that we were unable to account for in this study are likely to result in non-differential misclassifications of total personal exposure to PM, ultimately biasing associations towards the null.
The main limitation is the exposure misclassification in modeled air pollution concentrations, since these are only proxies of personal exposure.
The main limitation of this study is the possible exposure misclassification of modeled air pollution concentrations at residence, which are only proxies of personal exposure.
However, some studies have methodological limitations due to lack of objective measurement of personal exposures and indoor air quality leading to potential misclassification.
Although a reasonable correlation between personal and work area measures of airborne endotoxin has been observed in the Shanghai cotton textile industry (Mehta et al. 2008), the lack of personal air sampling data may be a possible source of exposure misclassification for this study.
Our study depended on the self-reporting of personal and family atopic disorders and this may have resulted in the misclassification of atopy.
Our reliance on microenvironmental samples, instead of personal samplers for each worker for each shift also likely lead to increased exposure misclassification.
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