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When laboratory Reference Ranges (RR) do not reflect analytical methodology, result interpretation can cause misclassification of patients and inappropriate management.
In addition, fluorescence in situ hybridization (FISH) probes may not be sensitive enough to identify small deletions in TP53, such as exonic or promoter deletions, resulting in misclassification of patients.
Another problem of interest is the time point of hyperoxia exposure, which can lead to misclassification of patients.
The study was designed to accurately define and harmonize TPOAbs URLs in order to avoid misclassification of patients in the process of AITD diagnosis.
Hence, further efforts in defining the threshold values of positivity need to be made in order to avoid misclassification of patients with AITD [9].
In addition, studies with questionable DM ascertainment were excluded in order to minimize misclassification of patients.
Other factors, including comorbidity medical conditions that mimic asthma such as vocal cord dysfunction, may also lead to potential misclassification of patients with severe asthma [22].
It is possible that misclassification of patients as LTFU instead of transferred-out was differentially increased at regional hospitals compared to other facilities, as regional hospitals had the highest rates of transfer-out and the highest patient loads predisposing to data capture error; this may falsely elevate LTFU at regional hospitals although the magnitude is unlikely to be large.
As such, there is potential for misclassification of patients.
The misclassification of patients could result in skewing of the hazard ratio towards the null.
There may be some misclassification of patients using these proxy measures.
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