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Diagnostic codes used in administrative databases cause bias due to misclassification of patient disease status.
Misclassification of patient race/ethnicity is well described in cancer registry data and may have influenced our analyses.
We acknowledge that the small false positive (1/1000) and false negative (1/10,000) match rate inherent in automated fingerprinting systems may cause misclassification of patient data.
It is precisely the divergence at higher values reported in our paper (i.e. those more likely to be associated with brain damage) that may cause misclassification of patient status and prognosis; hence the need for standardization.
Reasons for the extensive contamination of surfaces in unexposed patient rooms may include transfer of pathogens via hands or fomites of staff, patients, and visitors; misclassification of patient rooms due to unidentified colonization status of individuals; or failure of routine cleaning and disinfection practices.
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When laboratory Reference Ranges (RR) do not reflect analytical methodology, result interpretation can cause misclassification of patients and inappropriate management.
Another problem of interest is the time point of hyperoxia exposure, which can lead to misclassification of patients.
The study was designed to accurately define and harmonize TPOAbs URLs in order to avoid misclassification of patients in the process of AITD diagnosis.
Hence, further efforts in defining the threshold values of positivity need to be made in order to avoid misclassification of patients with AITD [9].
In addition, studies with questionable DM ascertainment were excluded in order to minimize misclassification of patients.
Other factors, including comorbidity medical conditions that mimic asthma such as vocal cord dysfunction, may also lead to potential misclassification of patients with severe asthma [22].
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