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Possibly we failed to identify some relapses, leading to misclassification of outcomes.
Misclassification of outcomes should not differ by ethnic group and would tend to bias our results toward the null.
Fourth, the register-based cohort design ensures temporality and minimises loss to follow-up and misclassification of outcomes.
Misclassification of outcomes and drug use may occur in observational studies that rely on healthcare databases and discharge codes.
In addition, the registries of cancer, stroke, and myocardial infarction were of sufficient quality to reduce the misclassification of outcomes.
38 39 We only used primary diagnosis, which should reduce misclassification of outcomes, 40 and our analyses of combined cardiovascular disease outcomes are unlikely to have significant misclassification.
Similar(44)
Much attention has been drawn to the problems that might, in theory, bedevil this approach, including confounding from population structure, misclassification of outcome, and allelic heterogeneity.
Our study has several strengths like all our control subjects were under Hardy-Weinberg equilibrium minimizing population stratification, all our cases were histopathologically confirmed minimizing misclassification of outcome and cases and controls were matched for age and gender.
However, misclassification of outcome is unlikely to differ across categories of birth conditions.
Hence, there might be substantial misclassification of outcome status biasing the odds ratios and prevalence estimates.
Additionally, we only included infants with Dubowitz assessment to reduce misclassification of outcome.
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