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This difference in coding does not introduce risk of misclassification of deaths.
First, deaths from P&I were not always confirmed by laboratory methods, which could have resulted in misclassification of deaths.
Some misclassification of deaths could have occurred but evidence from methodological comparative studies suggest that risk estimates are unlikely to be greatly affected [ 35].
Second, despite a focus on atherosclerotic/thrombotic events, we did include fatal CHF in the primary end point to avoid misclassification of deaths from unrecognized ischemic CHF.
There is a risk that this may lead to the misclassification of deaths, and possibly an underestimation of the burden of sepsis-related mortality.
Another matter for concern is the possibility of misreporting or misclassification of deaths from induced abortion as deaths for other causes, for example, haemorrhage or sepsis.
Similar(48)
There is also the potential for misclassification of death [71 74].
Also, using data from a mortality registry is likely to result in some misclassification of death cause and particularly some underreporting of contributing causes of death.
For example, apparent inconsistencies in some observations from cohort studies of American workers, which were primarily based on mortality, and cohort studies of Nordic workers, which were largely based on incidence, may reflect misclassification of death certificates compared with incidence data.
Meanwhile, the Murray et al. method suffers, by necessity, on a reliance on uncertain models for mortality in most of the settings with largest epidemics, and elsewhere is subject to questions about the extent to which verbal autopsy data can be relied upon [ 31, 32] and the difficulties of adjusting for misclassification of death caused by AIDS.
Their methodology included examining registration statistics and verbal autopsy data, and correcting agreed-upon misclassifications of deaths from categories such as "fever" and attributing them to malaria.
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