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Nevertheless, differential and nondifferential misclassification may limit the validity of findings based on retrospective assessment of exposures.
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However, urinary BPA concentrations were relatively low in our study population, enhancing the analytical uncertainties and hence the potential for exposure misclassification, which may limit our ability to distinguish monotonic from nonmonotonic associations.
Nevertheless, such misclassification may have limited our ability to detect an association and we are unable to exclude a modest association between passive smoking and breast cancer.
Exposure misclassification is also a concern in the AHS and may limit the analysis of exposure response patterns.
This may limit the interpretation of the results through a misclassification of exposure.
Different levels of exposure misclassification may lead to different levels of bias in the effect estimates, limiting to some extent the conclusions that can be drawn from a comparison of effect sizes for different pollutants.
There are two situations where the individual probability of misclassification may differ significantly from the average probability of misclassification (i.e. the prediction error).
This exclusion and misclassification may have underestimated the effects observed in this study.
Hence, misclassification may have led to conservative estimates.
Such misclassification may have biased the results.
Hence the consequences of a misclassification may be very serious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com