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A plausible reason for this misclassification is that gene expression in these samples may not be significantly different from that in the controls due to low levels of contaminant.
One possible explanation for our misclassification is that we built classifiers based on gene expression profiles of 20 ALL and 28 AML patients from a single cohort.
Another issue that could lead to misclassification is that serum T4 was measured as total T4 rather than as free T4 (the physiologically available form).
The reason for the misclassification is that the classifier recognized these proteins as having very similar characteristics to disease-related proteins based on the attributes provided.
However, one special problem associated to exposure misclassification is that a previous pregnancy ending as a fetal loss does not reduce the organochlorine level as much as a pregnancy ending as a live birth, where the organochlorine level is reduced during lactation.
Similar(55)
Although digit preference (and other non-differential misclassification) can occur, the implication is that more respondents are required than would be the case with perfect information.
A misclassification is a feature that is classified as relevant by the feature selection procedure, whereas it is irrelevant or redundant according to the data generation procedure, and v.v.
Unfortunately, if misclassification is such that a large proportion of these behavioural variables (e.g., suicide attempts) are missed, it will lead to an under-estimation not only of the prevalence of the particular condition, but also may have an impact on effect size estimates of interest.
Risk of disease misclassification is a concern with studies that investigate prevalence rates.
It is possible that exposure misclassification is greater in Rural counties, which could introduce bias that would likely be toward the null, and may contribute to, or explain, the essentially null association in Rural counties.
In support of the idea that misclassification is likely to be non-differential, Kriegsman and others [ 21] found that depression did not influence the extent of agreement between self-reported and physician diagnoses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com