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However, if misclassification is present, it probably does not differ for vaccinated and nonvaccinated children.
In addition, the exposure metrics used in this study represent a major improvement in the classification of pesticide exposure over previous studies, although, undoubtedly, some exposure misclassification is present in our estimates as well.
Project investigators considering the use of self-reported values may be guided by these results in evaluating whether the potential for misclassification is present to an extent that suggests that measured values be derived.
Nonetheless, the validity of the diagnoses in the test sample (n=200) was comparable between low-incidence and high-incidence regions, so overall there is no reason to believe that systematic misclassification is present in the data analysed for this study.
Applying this theory to our findings, epidemiologic studies using a single house-dust endotoxin observation as an index of chronic exposure may underestimate the effect of endotoxin on an outcome, given that such an effect exists and no other bias or misclassification is present.
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The observed rate of TDR was higher than true TDR when misclassification was present and increased as the proportion of misclassification increased.
Using equation (1) (see Methods), as expected, the observed rate of TDR was higher than the rate of TDR in truly naive patients (true TDR) when misclassification was present, and increased as the proportion of misclassification increased.
In addition, the differences between the ideal trajectory and the trajectory including the effect of misclassification are presented in Fig. 8.
To the extent that misclassification of exposures is present, we expect that it would be nondifferential (i.e., not associated with %FGV or salivary hormone levels), and would thus bias the results toward the null.
Whilst we visually checked data points for obvious errors, it is likely that some misclassification is still present, although it is likely to be non-differential.
Second, some exposure non-differential misclassification is invariably present which tends (in expectation) to make the slope of the exposure-response line shallower than the true one, leading to an underestimate of the attributable proportion.
More suggestions(15)
error is present
misclassification is low
misclassification is possible
misclassification is variable
misclassification is probable
misclassification is pivotal
misclassification is bad
misclassification is unlikely
misclassification is critical
misclassification is unknown
misclassification is prevalent
misclassification is likely
misclassification is rare
misclassification is nondifferential
misclassification is inevitable
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