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As show in the figure, LDA can decrease the probability of misclassification caused by confusing words.
Another limitation is exposure misclassification caused by modeling procedures.
Using the average first trimester air pollution exposure attenuates any misclassification caused by, for example, travelling more than with a shorter time window.
First, as coffee consumption habits were self-reported and collected only once at the baseline, some misclassification caused by changes in coffee consumption during the follow-up period may have arisen.
The estimated effect modifications could be partially attributable to differential bias from exposure misclassification caused by some factors such as temperature, age, education and poverty because these factors are related to residential behaviors in communities.
Given that rs2476601 is a genetic risk factor for RA we were concerned that the observed p value in the discovery study was a false positive due to phenotype misclassification caused by the presence of unidentified RA samples in the case cohort.
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However, register data can involve misclassification problems caused by unrecorded cases and/or incorrect registration of diagnostic codes, and this limitation may have affected the validity of the data used in our study.
This study population was constructed specifically to avoid the misclassification of exposure caused by well switching.
Information bias (misclassification) may be caused by paucity of recorded clinical details or incomplete documentation of medication use.
Some exposure misclassification was likely caused by the fact that the cohort follow-up started in 1996 at the earliest, though finasteride was licensed in Finland in 1992.
29 30 Misclassification of BMI caused by self reporting nevertheless seems to affect all women equally, regardless of BMI, 31 which would lead to underestimates of the association between exposure and outcome.
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