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Autoimmune disruption may contribute to risk for autism; however, since previous studies relied upon clinical diagnoses, exposure misclassification and recall bias are limitations.
There are sources of bias that have been identified selection bias where patients included in the study were referred by primary care givers for a specified reason as well as misclassification and recall biases on certain information such as type and duration of physical activity.
However, the issues of misclassification and recall bias can be adequately addressed in the cohort studies included in the analyses.
Conflicting results may partially be due to many studies using self-reported methods such as questionnaires or recall interviews to assess PA [10], which are susceptible to misclassification and recall bias [11].
There may have been potential exposure misclassification and recall bias with cases over-reporting a "dusty environment".
Information bias - a) repeated measurements of outcomes (for asthma, eczema, and allergen skin test reactivity) should reduce misclassification and recall bias; b) clear definitions for primary outcomes and exposures; c) evaluation of outcomes is being performed blind to exposure status.
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Caveats of using these operational definitions and an unprecedented five year recall census (misclassification, underreporting and recall bias) have been extensively discussed elsewhere (8).
Questionnaire data, however, can suffer from biases (such as misclassification of exposure and recall bias) that decrease the validity of the collected information and may misrepresent the true association between two variables.
Additionally, some misclassification due to reporting and recall bias may have occurred as the data were based on information self-reported by the participants and therefore were dependent on their understanding of the questionnaire, their recall capacity and their willingness to respond accurately.
Traditional epidemiology studies evaluate human risk directly, at the exposure levels present in residences; however, these studies are limited by their potential for misclassification, biased recall, and uncontrolled confounding.
Self-reported information is often subject to misclassification, and a mother's recall of their child's experience may result in additional misclassification.
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misclassification and time
misclassification and awareness
misclassification and class
misclassification and underestimation
misclassification and bias
misclassification and transmitter
misclassification and under-diagnosis
misclassification and miscoding
misclassification and misinterpretation
misclassification and selection
misclassification and testing
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