The neuropsychological literature on mirrored-self misidentification suggests the involvement of the right hemisphere or frontal regions, but further anatomical specification has been hampered by the severe dementia and global cortical impairment of patients (Breen et al. 2001; Villarejo et al. 2011).
This process has been referred to as 'experience-based design' 24 and more recently as 'co-design.' 25 Mirroring the growing involvement of users in commercial product and service design, co-design combines meeting public demands and expectations, improving service consumer relationships and educating the public about what is (and what is not) feasible for a service or product to deliver.
It is therefore not surprising that the involvement of the mirror system translates the complexity of these representations.
We provide here experimental evidence supporting the involvement of the mirror system in the understanding of social intentions between two interacting agents.
As far as complex emotions are concerned, to date there is only behavioral evidence to suggest the involvement of a mirror-like mechanism in the automatic understanding of others' emotional states [8], [9].
A strength of this trial is the involvement of authentic teams that mirrored teams in real life that resembles the real clinical setting in every possible way.
A strength of this trial is the involvement of authentic teams that mirrored teams in real life, which seem to be of importance for the so-called sociological fidelity.
More specifically, this finding shows that the understanding of others' regret is mediated by the reactivation of the same core cerebral regions that induce the feeling of regret in the beholder during a first person experience, hence supporting the involvement of a resonance, mirror-like, mechanism in the comprehension of the high-order emotion of regret when experienced by others.
The involvement of frontal regions mirrors findings from the aMMN literature [10,33], and this correspondence corroborates suggestions for a multi-modal mechanism for the low-level detection of changes in the sensory environment [15].
Finally, gene expression data from primary tumours mirrored the finding that an EMT-like pathway is activated in resistant tumours relative to sensitive tumours, suggesting that the involvement of this transition may not be limited to in vitro drug effects.
