These effects mirror the phenotype seen in RUNX2 null animals where ossification is delayed, while over-expression leads to premature ossification [20] [22].
Of biological significance, treatment of E. coli with C7 rendered the organism more susceptible to C3 binding and serum killing, again mirroring the phenotype of an unencapsulated genetic mutant.
Thus, the progressing tumour mirrors the phenotype of the cell from which it arose (Visvader, 2011).
These findings mirror the phenotype of similar AP-positive aberrant cells observed in Blimp1−/− embryos, obtained by heterozygous crosses, at the same stage.
Again, chimeric BDNFind−/− mice exhibited a significantly enhanced motor impairment, thus mirroring the phenotype of BDNFind−/− mice treated with tamoxifen (Fig. 6a).
p53 heterozygosity markedly reduces lymphoma, sarcoma and epithelial tumour latency and mirrors the phenotype of LFS (Donehower et al, 1992; Jacks et al, 1994).
The inability of Nanog−/− cells to complete transcription-factor-based reprogramming mirrors the phenotype observed in Nanog null embryos, providing a model to study the unique role of Nanog during the acquisition of pluripotency in early development.
Expression of miR-203 significantly prolonged the time required for SCC13 and SJG15 cells to reach input levels of lung bioluminescence, suggesting that miR-203 extended the dormancy phase of engrafted cells, mirroring the phenotype observed in primary tumors.
As shown in Figure 4, Aroclor 1254 exposed wild-type and Wnt7a +/− uteri that had increased numbers of uterine glands at PND6 show a striking decrease in gland number at PND30, mirroring the phenotype observed in the DES-exposed uteri.
For example, it was shown that cultured glioma cells may show a "mesenchymal drift" due to transdifferentiation [ 127], and that GBM cells cultured in vitro with FGF and EGF more closely mirror the phenotype and genotype of the original tumors than GBM cells cultured in serum [ 98].
