Mirroring the depletion of circulating B cells, injections with the mAb 9B9 resulted in a 4 5 fold reduction of CD93−CD19+ mature splenic B cells.
The reduced numbers of lymphocytes and increased numbers of granulocytes in the paracortical areas of the mesenteric lymph nodes were mirrored by depletion of lymphocytes and increased numbers of granulocytes in the lamina propria of the small intestine (Fig. 5B, lower panel).
Interesting to note here is that for both HYS and MA, DAZ2 was found to be the transcript with the highest ratio of downregulation (~20-fold), which demonstrates that our gene expression data mirrors the depletion of DAZ transcripts as a consequence of the AZFc deletion.
This is equivalent to a screening potential (mirror charge) or depletion within the 2DEG due to the electrons inside the six QD states.
The expression changes observed after RAD21 depletion mirroring knockdown of Nanog further support this notion.
The best beam overlap is achieved in the region close to the mirror, where a maximum depletion of 90% is demonstrated in a single shot.
Thus, RAD21 knock-down mirrors expression changes observed after depletion of pluripotency transcriptional regulators.
The strongest evidence that the effects of surgically induced biliary diversion are mirrored by sequestrant-induced biliary depletion comes from the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) 13 and the NHLBI Type II Coronary Intervention Study.
Kosch et al. ([2007b]) showed that the pump beam forms a large-scale density depletion generating a reflective concave HF mirror which focuses the pump wave energy into a small region when pumping in the magnetic zenith.
These results mirror the phenotypic changes effected by the specific depletion of the CCT-eta subunit.
