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In addition, in PCV, the RR was controlled to keep minute ventilation constant (160 ml/min).

In addition, in PCV, the respiratory rate (RR) was controlled to keep minute ventilation constant at 160 ml/min.

Here, as well as keeping alveolar minute ventilation constant using Eq. (2), the inspiratory flow is also kept constant (this corresponds to the strategy implemented in [16]).

Thus, the simple formulae on which strategies 1 and 2 are based do not correctly compute the required changes in V T and RR to keep alveolar minute ventilation constant with either constant or variable inspiratory flow.

In addition, in PCV, the respiratory rate (RR) was controlled to keep minute ventilation constant (160 ml/min).

The patients presumably maintained their arterial carbon dioxide and minute ventilation constant by increasing neurological drive in response to the low pressure support.

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Similar(50)

Minute ventilation remained constant during both ventilation strategies, whereas the dead space/TV ratio was higher during low compared with high TV strategy.

At the various levels of pressure support applied, minute ventilation was constant, with large variations in breathing frequency/ tidal volume ratio.

The breathing pattern was significantly modified by changes in the level of pressure support, with large variations in the frequency/tidal volume ratio while the minute ventilation remained constant.

Moreover, since PETCO2 is mainly determined by tissue CO2 production (VCO2), alveolar ventilation and CO (that is, pulmonary blood flow) [17], when stable metabolic conditions are assumed and minute ventilation is kept constant, acute changes in PETCO2 have been shown to correlate strongly with changes in CO in experimental [18 24] and clinical [25, 26] settings.

Alternatively, in order to eliminate the influence of global respiratory alterations, minute ventilation should be constant.

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