Sentence examples for minute chromosomes from inspiring English sources

These amplifications are often seen at the cytogenetic level as homozygously staining regions (hsrs) or double minute chromosomes (dms).

In the KP1089-resistant subline multiple small DNA particles were observed by DAPI staining indicative for double minute chromosomes.

Cytogenetic studies demonstrated the presence of a large telocentric chromosome (M1) and two minute chromosomes (M2) not found in normal hamster cells.

Cytogenetic analysis of these cells revealed an unstable karyotype within a stemline range of 94 to 98 chromo-somes (the cells contain 6 to 10 large chromosomes with median or submedian centromeres and 2 to 4 minute chromosomes).

One of these is a fusion between EGFP and human histone H2B which was developed in order to label active chromatin and used to follow the segregation of double minute chromosomes in cancer cells [ 15].

In some cases, these massive rearrangements can lead to double minute chromosomes carrying oncogenes that are present in hundreds of copies (a lot higher than the maximum rate of 20 copies for any given gene that the authors presume).

We termed this method "Variety Update", which can be used to improve a less desirable trait of an elite variety by replacing only a minute chromosome fragment (Lin et al. 2009).

To achieve the high yield potential of Kongyu 131, a minute chromosome fragment carrying the favorable Gn1a allele from the donor parent was introgressed into the genome of Kongyu 131, which resulted in a larger panicle and subsequent yield increase in the new Kongyu 131.

Many of these were stitched together into a derivative chromosome 8, but 15 other fragments were joined to create a double minute chromosome of ∼1.1Mb in size (thick lines, Figure 6B).

Taken together, these findings are consistent with the model that the catastrophic shattering of chromosome 8 has facilitated the creation of a double minute chromosome, which, in this example, containing MYC, acts as a substrate for amplification, evolutionary selection and progression toward cancer.

HER2, TOP2A and STARD3 gene amplifications were found within chromosomes as homogeneously staining regions (HSRs) but not in extra-chromosomal, double-minute chromosomes (DMs).