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We used one minus survival plots based on the Cox regression to evaluate possible delays of the injury prevention effects of the programme in the intervention group compared with the control group.
The distribution of the difference between the two computed survival times (survival time according to HES data (HES-derived) minus survival time according to the cancer registry (registry-derived)) was extremely skewed.
The shape of the failure curves (1 minus survival) suggests that the protective effect of early physiotherapy remained for a long time, whereas the proportion of patients with a diagnosis of secondary lymphoedema in the control group increased progressively (fig 4).
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Kaplan-Meier cumulative 1-minus survival curves showed a continuous increase over time for any positive smear as well as for LSIL or more.
We assessed temporal mortality trends by comparing one-minus-survival curves that were constructed using the Kaplan-Meier method.
Using Kaplan-Meier one-minus-survival curve estimates, the 5-year MDS/AML cumulative incidence rate was.20%, the 10-year rate was.50% and the 15-year rate was.70%.70%
Assumptions underlying the Cox proportional hazards regression model were evaluated by log minus log survival and partial (Schönfeld) residuals versus survival time plots, and were found valid.
Cox regression analyses with time period as stratification factor were used to construct cumulative revision curves (1 minus cumulative survival) at mean values of the covariates, and to assess 5-year survival percentages.
We have used probability of revision (100% minus implant survival ) as a concept in the model, but since Norwegian practice traditionally gives implant survival (100-probability of revision), we calculate the corresponding 10-year implant survival by making an approximation that the probability of revision is the same from year to year (both values are given in Table A in the Additional file 1).
The cumulative incidence is then calculated as one minus this survival probability.
The Cox proportional hazards assumption was confirmed by plotting log minus log survival curves.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com